A neural basis for melanocortin-4 receptor–regulated appetite
نویسندگان
چکیده
منابع مشابه
Melanocortin activity in the amygdala controls appetite for dietary fat.
The amygdala is rich in melanocortin 4 receptors. Because the reduction in dietary fat intake after enterostatin is injected in the central nucleus of the amygdala (CeA) is blocked by a melanocortin 4 receptor antagonist, we investigated the role of melanocortin activity in the CeA in regulating food intake and macronutrient choice. Sprague-Dawley rats, fitted with CeA cannulas, were fed either...
متن کاملSalt appetite: its neuroendocrine basis.
Based on the early work of Richter (1936), showing that the adrenalectomized rat kept itself alive by drinking hypertonic NaCl solutions, Epstein and Stellar (1955) demonstrated that that salt appetite was innate, not dependent on learning. A series of later papers by Epstein and his students made clear that in addition to the adrenal steroid, aldosterone, salt appetite depended upon the action...
متن کاملA role for the melanocortin 4 receptor in sexual function.
By using a combination of genetic, pharmacological, and anatomical approaches, we show that the melanocortin 4 receptor (MC4R), implicated in the control of food intake and energy expenditure, also modulates erectile function and sexual behavior. Evidence supporting this notion is based on several findings: (i) a highly selective non-peptide MC4R agonist augments erectile activity initiated by ...
متن کاملa 3d model for human melanocortin 4 receptor refined with molecular dynamics simulation
despite a quite short early history, computational drug design and discovery methods can now be efficient in reducing costs and speeding up drug developing procedure. melanocortin-4 receptor (mc4r) is a g protein-coupled receptor implicated in the regulation of body weight. despite its clinical reputation, there is a lack of in-depth knowledge about structure and behavior of mc4r in lipid bilay...
متن کاملThe role of melanocortin-3 and -4 receptor in regulating appetite, energy homeostasis and neuroendocrine function in the pig.
A recently discovered class of receptors, melanocortin-3 and -4 receptor (MC3/4-R), are located within the brain and modulate feed intake in rodents. Stimulation of the receptor (agonist) inhibits feed intake whereas blockade (antagonist) of the receptor increases intake. Our knowledge of factors regulating voluntary feed intake in humans and domestic animals is very limited. i.c.v. administrat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Neuroscience
سال: 2015
ISSN: 1097-6256,1546-1726
DOI: 10.1038/nn.4011